First Week Dosing Schedule
Follow during your first week — or any period of increased joint discomfort.
| Time | Dose | Instructions |
|---|---|---|
| Upon Waking | 2 Capsules | Take on an empty stomach. Wait at least 1 hour before eating or drinking anything other than water. |
| Before Lunch | 2 Capsules | Take on an empty stomach, at least 1 hour before eating. |
| Evening | 2 Capsules | Take on an empty stomach — at least 1 hour before eating or 2 hours after your last meal. |
How the First Week Schedule Works
During periods of joint discomfort, the body may build a dense fibrin barrier around the joint space — preventing natural defenses and most supplements from reaching the affected area. The first-week schedule delivers concentrated support at key intervals across three phases:
High-potency systemic enzymes (Serrapeptase and Bromelain) enter the bloodstream. Taken on an empty stomach, they bypass digestion and target the joint space, supporting breakdown of fibrin that can block active ingredients from reaching affected areas.
Once the fibrin barrier is addressed, active anthocyanins from Tart Cherry and 3-n-butylphthalide (3nB) from Celery Seed saturate the tissue, supporting healthy xanthine oxidase activity to help maintain balanced uric acid levels.
Chanca Piedra supports renal tubule health, helping the kidneys filter and excrete uric acid more efficiently and maintain healthy clearance pathways.
Taking Gout Defense with food significantly reduces effectiveness. When food is present, Serrapeptase and Bromelain are consumed digesting dietary protein rather than entering systemic circulation to support joint spaces.
Do not exceed recommended use. Consult your healthcare provider before use if you are pregnant, nursing, taking medication, or have a medical condition — particularly bleeding disorders or pending surgeries, as systemic enzymes support healthy circulation. Discontinue use immediately if adverse reactions occur. Keep out of reach of children.
Built for Serious Inflammation & Joint Support
The enzyme delivery system designed to work at the source — not around it.
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Research References
- Proteolytic Enzymes in Joint Inflammation: International Journal of Cardiology — "Systemic Enzyme Therapy in Cardiovascular and Inflammatory Conditions: A Review of Serrapeptase."
- Xanthine Oxidase Support by Natural Anthocyanins: Journal of Agricultural and Food Chemistry — "Evaluation of Tart Cherry Anthocyanins as Inhibitors of Xanthine Oxidase."
- Kidney Clearance and Uricosuric Action: Journal of Ethnopharmacology — "Phyllanthus niruri (Chanca Piedra) and its effects on uric acid excretion and renal stones."